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Author Topic: Update: Almost Two Weeks In (Prozac and Propranolol)  (Read 238 times)

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Offline poppadr3w

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Update: Almost Two Weeks In (Prozac and Propranolol)
« on: March 29, 2014, 09:53:09 PM »
It has been almost two weeks (This coming Monday) since I've been on my new medicines.

I was on Paxil (generic) for a couple of weeks prior if you all remember, and then I went to a my Psychiatrist and he put me on the Prozac in a stepped regiment and Propranolol 10mg 3x/day. The Prozac are 10mg tablets, but he told me to break it in half the first four days and increase it 5mg every four days. So 5 then 10 then 15, then 20 and finally 25. I just started 20mg tonight.

I'm still feeling... Out of it. Kind of even moreso, and I still get anxious. I feel the beta blocker helps a lot for the physical aspects of the anxiety (Most of the time, at least).  He also said I can still take Xanax as needed, so I'll take .25mg in the morning usually or later in the day if I need to.

How much longer do you think it'll take the Prozac to take effect? I am starting to feel a bit depressed (Especially today). I feel like I am missing so much and that time is going by so fast, so that compounds the feelings of sadness. My girlfriend is out bowling with some friends tonight, and I am stuck here... She understands, but I want to, you know, be out there enjoying myself. I am 25 and this has been going on for some time now (On and off, but for the past couple of months it has been to the point where I don't feel well enough to even go out to any social places). Last year for my birthday after my anxiety flared up I didn't do anything, really. That was before I knew it was anxiety -- I thought it was gastrointestinal.

Any advice? I also take it at night, although I don't feel that it makes me sleepy. I figured that'd be best just in case it were to when I first started taking it.

Also, would taking the Paxil for two weeks prior and then switching to the Prozac make the Prozac take longer to work in any way or mess with it?

Like I said, I just want this stress gone... These feelings of stress. If I go out I feel like my chest tightens, it gets harder to breathe and I'll even, at times get bad acid reflux. In February I had such a bad attack that I couldn't eat or drink anything without getting chest pain.

I've had all of the testing done... CAT Scan, MRI (Head), Cranial Doppler, Endoscopy, EKG, Stress Test, Holter Monitor, Echocardiogram, Stomach Sonogram. I've been to so many specialists - Gastroenterologists, Psychiatrists, Acupuncturists, Chiropractors, General Physicians, Orthopedists, Urologists, and to the hospital many-a-times. I feel like I am going crazy with this. On one hand I am glad that nothing can be found, on the other hand I am getting upset that, well... There's nothing definitive causing my symptoms. At least with an ulcer or something physical it can be seen... This seems to be psychological with physical manifestations.

Sorry for the rant.

Advice?
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Offline insights

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Re: Update: Almost Two Weeks In (Prozac and Propranolol)
« Reply #1 on: March 29, 2014, 10:54:51 PM »
How much longer do you think it'll take the Prozac to take effect? I am starting to feel a bit depressed (Especially today).

As with all antidepressants, 3-12 weeks from when you're at a therapeutic dose, which for Prozac is usually 20mg/day. It tends to be a slow starter because the very long half-life means it doesn't achieve steady plasma levels for about a month, although those with depression may notice a lift in mood sooner than this.

Quote
Also, would taking the Paxil for two weeks prior and then switching to the Prozac make the Prozac take longer to work in any way or mess with it?

It may slightly hasten kick-in.

Quote
This seems to be psychological with physical manifestations

It is a physical brain disorder which masquerades as a psychological one producing physical symptoms. It can be moderated by psychological means, but it is still just as much a physical disorder as a broken leg.

Ian

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NOTE: I'm not a doctor, and particularly not yours, so there may be factors I'm unaware of. Therefore all advice is of a general nature and you should consult your doctor before following any of it, especially before changing med doses.

Offline poppadr3w

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Re: Update: Almost Two Weeks In (Prozac and Propranolol)
« Reply #2 on: March 29, 2014, 11:06:01 PM »
How much longer do you think it'll take the Prozac to take effect? I am starting to feel a bit depressed (Especially today).

As with all antidepressants, 3-12 weeks from when you're at a therapeutic dose, which for Prozac is usually 20mg/day. It tends to be a slow starter because the very long half-life means it doesn't achieve steady plasma levels for about a month, although those with depression may notice a lift in mood sooner than this.

Quote
Also, would taking the Paxil for two weeks prior and then switching to the Prozac make the Prozac take longer to work in any way or mess with it?

It may slightly hasten kick-in.

Quote
This seems to be psychological with physical manifestations

It is a physical brain disorder which masquerades as a psychological one producing physical symptoms. It can be moderated by psychological means, but it is still just as much a physical disorder as a broken leg.

Ian

Ah Ian, I always take comfort in your rapid and informative replies. I am glad that someone that knows so much about these medicines responds in such a quick manner.

I obviously just want to feel better, so hopefully being on the Paxil does hasten it.

Tonight was my first dose of 20mg. I take three more doses of that and then move up to and sit at 25mg until I see him again in a couple of weeks.

One more question, and I know this may be difficult to answer: If I took Prozac awhile ago (In high school) and it worked, will it have a high change of working now? I know that our body chemistry changes, which is why I am asking.

And you're right about it being physical. I remember my first panic attack - sheer terror. Many people do not understand until it happens to them. Then even the physical manifestations without the feelings of anxiety. It just screws with your mind... I'd feel ok psychologically, but then my stomach would churn and burn and I'd get dizzy.

Thanks again for your quick response.
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Re: Update: Almost Two Weeks In (Prozac and Propranolol)
« Reply #3 on: March 29, 2014, 11:26:59 PM »
If I took Prozac awhile ago (In high school) and it worked, will it have a high change of working now? I know that our body chemistry changes, which is why I am asking.

Yes, and no. Yes, the fact it has worked before shows it is probably a good fit for your physiology. No, in that there is growing evidence that antidepressants can become less effective every time they are stopped and restarted. And it's not just if you've been on the specific antidepressant before, but any of them. Even your short time on Paxil may have contributed to this. But the chances are still good that Prozac will work well for you, though you may need to take a higher dose than in high school to achieve the same result, and the startup side-effects might be more severe too.

Quote
I'd feel ok psychologically, but then my stomach would churn and burn and I'd get dizzy.

As I just posted in another thread, there is a reason anxiety and stress affect the gut, it has it's own brain, the enteric nervous system (ENS), which is an much bigger user of serotonin than the brain, about 95% of all the serotonin made in the body occurs in the gut compared to less than 2% in the brain. The ENS doesn't just regulate the GI tract, but is a major influence on mood too, and via the vagus nerves can also affect the heart and lungs. It  is an organ with which you shouldn't mess as it can make life pretty miserable across many organs if upset.

PS: See also.

Ian
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NOTE: I'm not a doctor, and particularly not yours, so there may be factors I'm unaware of. Therefore all advice is of a general nature and you should consult your doctor before following any of it, especially before changing med doses.

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