I don't have twitching, but I have fasciculations. They are 2 different things. I have had fasciculations for a year now. I went and had an eval by a neurologist and since my EMG is normal and the MRI of my brain is normal, that means there is no "pathological" cause so thus I have Benign Fasciculation Syndrome. I get them all day long nonstop and they jump from place to place all over my body, mostly in my face and arms and back. Well, Zoloft can cause that, which i have been on for over a decade so I am going to stop taking the zoloft to see if they go away. I have also been checked for lymes, magnesium deficiency, and celiac disease, also had creatinine kinase checked. It has to be the zoloft. Even it says so that that is an adverse reaction from it. I have been on 50 mg zoloft once per day all these years. So today i started to taper down to 25 mg, and i will stay on 25 mg i am thinking at least 2 months, then take it every other day, then every couple days... so i plan to do this for about a 6 month period. I had less fasciculations today. That could just be coincidence though. Do you take zoloft or any other SSRI?