I think many folks find there is a daily pattern to anxiety and/or depression. I have a friend who has only depression, for him he wakes up fine but is feeling really bad by evening (but medication has worked along with therapy for him for many years). I have anxiety, have had panic attacks in the past, and definitely have depression this time around, usually after feeling anxious, and it follows a clear pattern of waking up to dread or feeling really bad physically (fatigue, stomach stuff, etc, the usual), usually getting better during the day especially if I am busy and around people, then getting almost normal before bedtime. I wonder why no one has looked at these patterns (at least that I am aware of) because they probably could be helpful in better classifying the conditions and determining the best treatments. For my pattern, my guess is that cortisol levels are at their highest when its time to wake up, and they add to anxiety, they are lowest when its time to go to sleep. When I have had full remission in the past (usually on medication) a cup of tea sets my morning right as I am only tired, but no caffeine for me before I get there again.