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Well its been over a year, and I had a fairly long stretch of generally good days while working but still feel like I have not got full remission yet from my combination of Lexapro 15 mg, klonopin (1 mg, .5 at night, .25 on waking and .25 around 4), fish oil pills (2) and Deplin (15 mg),
The last few days I have had a bit of a setback, I feel more anxious and depressed, and I know there are some triggers (week at work involved less interaction with people, it was quieter than usual) and my wife has to work this and next weekends, and I generally feel better when she is around....but then again I may feel better in a couple of days when work begins again.
My pdoc is thinking about switching me to Pristiq, she says it along with Lexapro seem to be the best tolerated for folks in her practice. She said Cymbalta has too much trouble with insurance coverage when it needs to be raised to higher doses, and Pristiq has some advantages over its parent Effexor.
I'm also afraid of doing a switchover for fear of a difficult adjustment, and also finding out that maybe it doesn't work. Also I would hope that if I did this that it would not poop out on me for a long time if ever, and if it did, might the Lexapro work again after not taking it at all for a while.
Also took a little walk around the neighborhood, weather was finally decent enough to do so (its been horribly cold where I am for weeks)
serzone which seemed to work for years with no side effects that I recall until it just quit one day
then to Lexapro which was wonderful for about a decade though I lowered the dose over time from 10 (felt a little tired and it had sexual effects though not as bad as zoloft) to 5 (that was good, should have stopped there, then to crumbs, big mistake.
I have not been on an SNRI yet, and my experience with nortriptylene wasn't great in the sense that it made my pulse rate go fast, get some heart skips, and I was tired, though I did sleep well.
I figured that since I quit the deplin a week ago maybe that caused the slump? Its expensive stuff, and I am heterozygous for the gene that converts folic acid to methylfoliate (which is what deplin is) so I don't know how much I really need the deplin, because while I don't convert folic acid as efficiently as a homozygous normal does, I am still able to convert something like 60 to 80 percent efficiency if I am reading correctly--plus half the population is either heterozygous or, worse, homozygous recessive, for this gene.
I do have a liver cyst though, one of a few "harmless" but disconcerting things I learned from a CAT scan with and without contrast near the end of last year, the other was a small patch of dead bone below my left shoulder
I looked up more stuff on Pristiq and Amitryptilene, seems some folks have stomach issues on the pristiq which I have when my anxiety acts up (gurgles pain etc)
and the tricyclics as a rule seem to make people tired and can speed up the heart, which I really don't need if I can avoid it