Does anyone on here take natural supplements for anxiety? Does it help? And what do you take? TIA
The only natural treatments with a goodish track record for mild to moderate anxiety are Omega-3 fatty acids/fishoil oil, and exercise. Some of the others may help with very mild anxiety. None will do much for severe anxiety and panic attacks. For these the only treatments that are as effective as antidepressants and benzodiazepines are the cognitive and/or behavioural and/or mindfulness therapies.
This is inaccurate. Niacinamide ( vitamin b 3) is much more effective than omega 3 fatty acids. Works similar to a benzodiazepine. Lots of people turn to Niacinamide when trying to ween off benzos, check out benzo buddies. It's safe, and does not produce dependence. Safety has been demonstrated up to 3 grams daily.http://www.ncbi.nlm.nih.gov/pubmed/7913840http://www.ncbi.nlm.nih.gov/pubmed/8588246
Journal of Orthomolecular Medicine Vol. 20, No. 3, 2005
Another biochemical reason for niacinamide’s anxiolytic effects might have to do with the vital role that it has upon the synthesis of serotonin.
For example, in a patient with anorexia nervosa an insufficient supply of vitamin B3 or protein resulted in reduced urinary levels of the serotonin breakdown product, 5-hydroxy-indolacetic acid (5-HIAA).32 The authors of this report postulated that a deficiency of vitamin B3 reduced the feedback inhibition upon the kynurenine pathway, resulting in more tryptophan being diverted to the kynurenine pathway, making less substrate available for the synthesis of serotonin.
By contrast, the use of pharmacological doses of vitamin B3 can increase the production of serotonin.33 In a rat study, the administration of 20 mg of niacin resulted in increased levels of 5-HIAA and decreased levels of xanthurenic acid via the kynurenine pathway.34 Taking pharmacological doses of niacinamide (or any other form of vitamin B3) would increase the production of serotonin, by diverting more tryptophan to become substrate for serotonin synthesis. Niacinamide’s therapeutic ability to increase serotonin production might explain why it was successful in reducing the anxiety symptoms of the three patients"
Excess nicotinamide increases plasma serotonin and histamine levels.
Tian YJ, Li D, Ma Q, Gu XY, Guo M, Lun YZ, Sun WP, Wang XY, Cao Y, Zhou SS.
Institute of Basic Medical Sciences, Medical College, Dalian University, Dalian 116622, China; Department of Neurology, Zhongshan Hospital Affiliated to Dalian University, Dalian 116001, China; College of Environmental and Chemical Engineering, Dalian University, Dalian 116622, China; Department of Physiology, Institute of Basic Medical Sciences, China Medical University, Shenyang 110001, China. E-mail: firstname.lastname@example.org
Methylation, a methyl group-consuming reaction, plays a key role in the degradation (i.e., inactivation) of monoamine neurotransmitters, including catecholamines, serotonin and histamine. Without labile methyl groups, the methylation-mediated degradation cannot take place. Although high niacin (nicotinic acid and nicotinamide) intake, which is very common nowadays, is known to deplete the body's methyl-group pool, its effect on monoamine-neurotransmitter degradation is not well understood. The aim of this article was to investigate the effect of excess nicotinamide on the levels of plasma serotonin and histamine in healthy subjects. Urine and venous blood samples were collected from nine healthy male volunteers before and after oral loading with 100 mg nicotinamide. Plasma N(1)-methylnicotinamide, urinary N(1)-methyl-2-pyridone-5-carboxamide (2-Py), and plasma betaine levels were measured by using high-performance liquid chromatography (HPLC). Plasma concentrations of choline, serotonin and histamine were measured using commercial kits. The results showed that the plasma N(1)-methylnicotinamide level and the urinary excretion of 2-Py significantly increased after oral loading with 100 mg nicotinamide, which was accompanied with a decrease in the methyl-group donor betaine. Compared with those before nicotinamide load, five-hour postload plasma serotonin and histamine levels significantly increased. These results suggest that excess nicotinamide can disturb monoamine-neurotransmitter metabolism. These findings may be of significance in understanding the etiology of monoamine-related mental diseases, such as schizophrenia and autism (a neurodevelopmental disorder).http://www.actaps.com.cn/qikan/manage/wenzhang/2013-1-05.pdf