Ian, thank you for that very informative article. How do you know all this stuff? That's funny that you posted that because that is what my GI doc said... that i have diarrhea-predominant irritable bowel syndrome (but i never get constipation ever)... so it's prob just a motility issue. And yes, I do believe that stress and anxiety cause major gastrointestinal issues. When i had my colonoscopy, the procedure was deemed rather difficult, because my large bowel (colon) was so rigid that they had to apply a lot of abdominal pressure and readjustment of position to get the scope to the cecum. ANd that is when i was under propofol (sedated) so if my colon is that rigid when i am knocked out, no wonder why i have problems! I never had gastro issues until when i had amebiasis back in 2009 from vacation to florida... so possibly post-infectious IBS. I think it altered something in my flora. I have to ask your input on this Ian. End of december i had this bad head cold (but negative for flu). Then the head cold stopped. Then i had loose yellow stool for about 3 weeks with lots of mucus in it. Sometimes, i would just pass mucus and no stool. During this time period, that's when i was readjusting to being back on the zoloft. Also, during this time period, i had CBC with differential and my atypical lymphocytes were high at 5% (they should be zero). Mono test was negative (i had EBV when i was in high school). My segs were slightly high (neutrophils). Everything else was normal, the whole rest of my CBC, CMP, LFTs, thyroid function. During this time period is when i had my stool tested and it was positive WBCs but only 1+ (so that means 25%). Also during this time period is when i had my rheumatoid factor tested and it was slightly elevated. Also during that time period i was having bad joint pains in my large joints only (floating ribs, bilateral knees, and bilateral hips). So the doctor said i prob just had a self-limiting viral infection. What i have read in the medical literature is that if the range of atypical lymph is 5%, that is indicative of toxoplasmosis, parasitic infection, babesiosis, stuff like that. If it is greater than 10% that usually means mono from either EBV or cytolomegalovirus or HIV or hepatitis ( i do not have hepatitis or HIV). Also, adenovirus can cause this. So i wonder if that I was just having such a tough time because of the going off zoloft, then going back on it, then i had caught a viral thing... and all that together, which was just bad timing, made my results abnormal. Do you think zoloft can do that? Most recently, i had what was probably norovirus about a week ago but am all better now. That was brutal. For about 24 hours... fever of 101, i threw up around 12 times, and had straight watery diarrhea about 15 times. But it was only for like about 24 hours. I work in a hospital in a GI practice so I'm always around germs and stuff. I wash my hands all the time and am very careful... but you can't help when people are coming in sick and they cough and sneeze right in your face! Ewwww! I do have to say we have a new company in clinical trial... they are doing PCR DNA stool tests to check for H pylori and like 20 other pathogens (because biopsy of EGD can sometimes miss H pylori, but DNA in stool will pick it up) so i volunteered to send in a sample (cause its for free) and i will get my results today, so i will post my results. They are especially interested in me... because i had duodenal lymphocytosis with mild crypt hyperplasia (that finding is rare, it only is found in like 4% of biopsy results, and can be indicative of many things including H pylori and celiac, but H pylori was negative by biopsy and celiac bloodwork was negative as i had DNA test and i do not carry the celiac genes, DQ2 and DQ8). So they are interested in my case because i could be one of the people that actually might have H pylori but biopsy missed it for one reason or another, and that is what caused the increase in duodenal IELs. Very interesting to me! And if that is the case, no big deal, you just take an antibiotic regimen to eradicate the bacterium. And if that test is negative, then yes, i do believe it;s just irritable bowel due to anxiety issues and no further testing is warranted. What do you think???