I took combination birth control pills for years and never had any problems with anxiety. After the birth of my second child, I didn't want to go back on combination birth control because I was 31 and a smoker. I had the Mirena inserted when I was 34, thinking it would be perfect for me. Within two months of insertion, I was a basket case; one minute I was fine, the next minute I was suicidal -- no joke. It was the single most terrifying experience of my life. The doctors kept saying I was depressed, but I WASN'T depressed! I was fine before this horrible thing. I went from a size 12 to a size 6 in six weeks; my entire existence was one long panic attack. I cried constantly, shook constantly, lost my appetite, had suicidal (and other scary) thoughts -- I wasn't depressed before the Mirena, but I sure as hell was afterward, so I reluctantly agreed to take Zoloft, and gained all of that weight back. After about a year, I thought it would be okay for me to taper off of the Zoloft (because of weight and lethargy issues) since I had long before had the Mirena removed. Within a month, the panic attacks started again. So, here I am, six years later, still popping Xanax and going on and off the Zoloft for anxiety and panic attacks. Mirena ruined my life, no bones about it.
I've done a lot of research, and of the women who posted online about anxiety and panic with the Mirena, a lot of them mentioned that they have a tilted uterus (as do I); this could possibly be a contributing factor in our intolerance of the IUD (maybe the weird angle causes the hormone to be released more rapidly). The other possibility is that, maybe I'm just a "yin/yang" person...maybe I need the balance of BOTH hormones...maybe ONE hormone knocked me so out of whack with the other hormone that I'll never be myself again.