Hi! I am 34 years old. I had an EGD last april which was negative for H pylori (helicobacter pylori is a common bacterial infection about 2/3 of the world has... if you have it, you take antibiotics to get rid of it). My duodenum (which is the first part of small intestine) was irregular. On endoscopy, the entire duodenum had a granular appearance. A biopsy was taken, which showed duodenal lymphocytosis, especially at villous tips, and mild crypt hyperplasia. That can be indicative of celiac disease, NSAID usage, systemic autoimmune disorder, cystic fibrosis, or infection, or crohn's disease. Well i was negative for any type of infection, and I don't use NSAIDs. So then i had genotype testing to rule out celiac disease, and I was negative for the 2 genes which celiac people carry, which is DQ2 and DQ8 so the likelihood of me having celiac is like a 1% chance. So then i had a colonoscopy which was normal. 2 biopsies were taken to rule out microscopic colitis and they were negative. Now, the jejunum and ileum were the only 2 parts of my GI tract not gotten to. The jejunum is never reached through colonscopy or EGD. So then I had a CT abd and pelvis, and that was completely normal. So they say i probably just have diarrhea-predominant irritable bowel syndrome or unknown food sensitivity (not allergy... just an intolerance to something). I have done allergy testing and that was negative. I have done elimination dieting, such as Gluten-free, Paleo, and FODMAP diet. I seem to do best by avoiding gluten, preservatives, additives, and also by avoiding insoluble fiber. Wheat makes my stomach hurt. If i eat any type of vegetables, particularly lettuce, I will have loose yellow stool with undigested food particles in it. Now, it is normal to have undigested vegetables in stool, but i have excessive amounts. So the last test i had done, which i should get results today or tomorrow, is the fecal lactoferrin and fecal elastase. The lactoferrin would rule out inflammatory bowel disease, which i doubt i have. The elastase is to rule out exocrine pancreatic insufficiency, meaning my pancreas does not produce enough enzymes to break down food particles, like fats, proteins, and starches. The reason why they are testing that, is because i had high pancreatic levels in my first stool culture which could be indicative of pancreatic insufficiency, but it could just be negative, because the day before i dropped off my test i got really sick, that stool culture came back positive for salmonella and norovirus... double whammy! So i had to do another stool culture. But then I was reading about leaky gut syndrome. I do have enlarged crypts, in other words, so yes, in my opinion, that does mean increased intestinal permeability meaning food and toxins that should not leak through will leak through into my bloodstream and cause a toxic like reaction. Now, I think the leaky gut thing is more thought to be a holistic type thing, not really accepted as of yet in mainstream medicine. But once you repair the leaky gut then you can go back to normal diet. These are my symptoms: for a while i was getting bouts of diarrhea up to about 10 times a day maybe like once a month. At one point for about a month i was passing a lot of mucus in stool, or sometimes i would just poop out mucus and no stool. Sometimes i get a mild pain in my left upper quadrant. When i eat gluten or a lot of sugar, i get roaming joint pains in my ribs, knees, and hips. I will get a headache. My eyes will feel blurry and itchy. Sometimes i might have an ocular migraine. My thinking gets messed up, which causes me to have increased anxiety type feelings. I can't focus. I feel like my mouth doesn't work right. Right now I am doing gluten free again and i do feel better. I am not allergic to gluten or wheat, and i do not have celiac, but i do think when i eat it, it effects me because it leaks through my leaky gut and causes an inflammatory response of some kind that effects my brain-gut connection. I am a big believer in that. When i am gluten-free and low carb/low sugar i do not have diarrhea. But vegetables cause me to have yellow stool, still. Also, when i am gluten free i do not have anxiety and weird feelings as stated above. I read to cure leaky gut, you need to remain gluten-free, dairy-free, and no NSAIDS. Also, a supplement called glutamine will help, which i just ordered, but have not taken it yet. I do not drink at all. I do smoke. My labs are always normal (CBC, CMP, LFTS and thyroid). The only thing abnormal was my redblood cell morphology, which shows 1+ (meaning 25%) poikilocytosis and ovalocytosis, which means irregular shaped cells. My atypical lymph was abnormal too at 5, but that could be because i think i had a viral flu-type illness when i had that checked, which was 2 months before the salmonella and norovirus infection. My ANA was negative. My rheumatoid factor was elevated but not enough to be considered rheum arthritis and i dont have any nodules or pains in little joints so that meant no RA. So basically i have had tons of testing, and Im done with testing, and through my own elimination dieting, i have come up with that i have leaky gut and need to avoid gluten and stay on low fat diet which seems to work really well for me. I will post my findings of the pancreas thing if i get them back today.