I've been on zoloft for years, not in a row but one year in a row minimum. I started with the minimum, 25mg if I remember correctly. I felt weird for the first week, nauseous just a bit, digestive issues for the first 2-3 days. Tiredness, a bit of dizziness, a little headache...everything most disappeared after a week. Some stuff was still there: little tremors sometimes, slow vision focus, little dizziness sometimes (I think I was not drinking enough and it was not helping), sweating more easily. Nothing scary, really. It worked good for anxiety. Zoloft was a nice help. I've been up to 150 and even 200 for a short time. I spent most of the time at 150. Zoloft comes in powder so it's a mess when you want to split it if you really need to do it. It's also a bit rough for the stomach, but no problem if you take it with food. I got insomnia with it until I take it before to sleep. Insomnia disappeared then. With time I really forgot any little nuisances that zoloft can bring. It was just good to be able to live again. Ah yes I should say that alcohol with zoloft was not a problem, but I never drink a lot in one shot anyway.
For klonopin, I've never tried.