I know very little, so take I what I say with a grain of salt: I believe twitching all over is actually a good sign, this came straight from the mouth of my neurologist. If ONE leg were weak and that ONE leg was the only one twitching, I'd be a little concerned. From what I understand, ONE leg would be weak and the other would be normal if it were A%$. A%$ progressively moves throughout the body. I've had body wide twitching for over a year and half now. I've often had PERCEIVED weakness in one of my legs. While my leg FELT weak, I had an EMG and it came back clean. There is an entire website of (5000+ members) devoted to people who twitch and believe it's A%$.