Thanks Ian, for this deeply referenced & deeply scientific response. I admit to knowing nothing about biochemistry & receptors (I'm a musician and craftsman who did poorly in high-school of chemistry & biology
,) but it appears you and all these other referenced people are clear about the temporary/changing nature of receptors and their inability to assume one frozen form due to prolonged BZD use.
It's just that there's so much
talk about BZDS down-regulating GABA receptors, and that biological action being the main
reason for anxiety-based dependence on them, not only in benzo-scared forums like the one I alluded to and Ahston's own manual, but all across the Internet. If you type in a phrase like "benzodiazepines turn-off GABA receptors," or something like that, you get hundreds of pages attesting to some way in which the GABA you need your body to produce, to have less anxiety, is somehow switched off for as much as a year or two after BZD use.
Based on your information, that's just patent nonsense. It makes me wonder how such a rich & prolific lie ever got started or sustained, and it makes me want to go back on the "other" forum and say, "Hey guys, all that stuff about BZDs blowing out your GABA receptors is crap, and here's the science behind it!"
But benzo-users & benzo-withdrawers have real, felt bodily symptoms and side fx beyond just rebound anxiety. Many develop insomnia, loss of creativity or emotion, memory problems, tinnitus & hearing issues, body pains, depression, depersonalization, the list goes on...so BZDs must be screwing with some
part of the brain or perhaps the thousands of receptors not in the brain. I sure you are aware there are GABA/BZ receptors throughout
the gastrointestinal tract and most other organs in the body.
So it's good to see scientific proof that tolerance & rebound anxiety is not a simple case of the benzos knocking out some permanent receptors that then need to "relearn" how to operate properly. But it still leaves much unexplained, and seems to leave BZDs in the category of drugs that could give many people some real bad problems, not the "quite safe" category.