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Author Topic: Latuda as monotherapy or adjunct, gotta love the merry-go-round  (Read 1315 times)

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Offline insights

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Re: Latuda as monotherapy or adjunct, gotta love the merry-go-round
« Reply #10 on: August 14, 2014, 08:08:36 PM »
how do you know so much about clinical trials?

I lead a dull, colourless and exceedingly boring life, so read a lot.  :winking0008:

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Is klonopin a good idea for long term hypomania treatment? or are the atypical AP's/anti seizure meds a better route?

Depends on how frequent and long-lived the hypo mania episodes are. If they occur infrequently and don't last for more than a couple of weeks then Klonopin would be as good as anything else and with fewer potential side-effects. But if they occur frequently or last longer then the other options may be better.

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Klonopin works for anger?

Maybe. It isn't a specific property, but it may help by lowering stress levels. If anger is a significant issue then the mood stabilizers would be better, though anger management training might be the best solution.

Ian
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NOTE: I'm not a doctor, and particularly not yours, so there may be factors I'm unaware of. Therefore all advice is of a general nature and you should consult your doctor before following any of it, especially before changing med doses.

Offline dannysmiles19

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Re: Latuda as monotherapy or adjunct, gotta love the merry-go-round
« Reply #11 on: August 17, 2014, 12:19:19 AM »
Ian, psychiatrists just don't serve me well. I have had some crap luck. I have to just stop believing labels. The doctor I had an intake with today didn't think I was bipolar and suspects just unipolar depression... this is so annoying. I thought I was bipolar...now I have to have the mentality that I'm unipolar.

I worry about it because of the treatment differences...but this doctor explained that lamictal and lithium and latuda can treat regular depression. But I'm so lost... I swear I experienced some kind of manic switching...i just don't know anymore. I guess from this point on I'm just gonna have the regular depression mentality again.

So this post wasn't all about that though lol He prescribed Brintellix and instructed me how to wean off cymbalta. brintellix isn't to be started until I get off cymbalta. he is keeping lamictal and said to take latuda at night... so what can I expect during this period possibly? any input? Weaning off cymbalta and simultaneously starting latuda... do you think I could still feel better during this period? I just want this to all be over 
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Offline insights

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Re: Latuda as monotherapy or adjunct, gotta love the merry-go-round
« Reply #12 on: August 17, 2014, 02:40:46 AM »
I worry about it because of the treatment differences...but this doctor explained that lamictal and lithium and latuda can treat regular depression.

Sure, but this doesn't mean they are the best option. Because of their side-effects profile  they should, IMHO, only be considered if there is no response to antidepressants.

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Weaning off cymbalta and simultaneously starting latuda... do you think I could still feel better during this period?

Perhaps, but I wouldn't count on it. People don't often feel better when either starting or stopping meds and doing both at the same time just adds to the potential issues. IMHO, changing two meds at once is not a good idea except in emergencies because if there is a problem it can be very difficult working out which med is causing it.

As for the Brintellix this is just another SSRI, but with the addition of a Buspar like compound. I think taking both a SSRI and Buspar is a better option because it is possible to fine tune the ratios instead of being stuck with the drug companies best guess. But it may be worth a shot.

Apart from Cymbalta have you taken any other non SSRIs as mono therapy? If so, what was the outcome?

Ian
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NOTE: I'm not a doctor, and particularly not yours, so there may be factors I'm unaware of. Therefore all advice is of a general nature and you should consult your doctor before following any of it, especially before changing med doses.

Offline dannysmiles19

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Re: Latuda as monotherapy or adjunct, gotta love the merry-go-round
« Reply #13 on: August 24, 2014, 02:18:16 AM »
Any non ssri's as monotherapy? No. It has been quite a journey with medications in such a short span of time. Here's the list:

Lexapro as monotherapy in january 2012. Mood swings to begin with and overall lethargic tired feeling most of the time.
Prozac given as monotherapy with leftover Benzo drugs for anxiety.
Wellbutrin, seroquil. remeron.
Lexapro again with Abilify
Viibryd as monotherapy
Cymbalta with Lamictal because of mood instability or lack of response
Now Lamictal and Latuda; tapering off of cymbalta and going to Vortioxetine

Latuda must be taken with 350 calories correct? I think that i need adjunct treatment or augmentation therapy. so latuda or lamictal or both seems like a good call. But maybe both isn't the right move.

So far, to be honest, cymbalta withdrawal so far has been a breeze compared to the horror stories. I am just having some head symptoms and that's it. cognitive shifts, yes, but overall im okay.

So... as of right now I truly believe I need depression medication because when I go off of these meds, my cognition and functionality plummet within months. How long does Latuda take again to do anything? and how will I know what pill I don't need?
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Offline dannysmiles19

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Re: Latuda as monotherapy or adjunct, gotta love the merry-go-round
« Reply #14 on: August 24, 2014, 02:20:39 AM »
and I think I like the anti depressants with a buspar like chemical because my response seemed to be good when I was feeling good. and my private area was functioning better (sorry if it's graphic). So maybe brintellix will work for me.
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Re: Latuda as monotherapy or adjunct, gotta love the merry-go-round
« Reply #15 on: August 24, 2014, 03:08:01 AM »
How long does Latuda take again to do anything?

You should notice a difference in a few days.

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and how will I know what pill I don't need?

Given the apparent scatter-gun approach your psychiatrist seems to be taking the only way will be to drop them one at a time to see whether your condition changes. IMHO, the correct way to do this is to prescribe one med, if it works well then no further action is required or if there's no response then drop it. However, if it has positive results but falls a little short of full effectiveness, or there are other symptoms which need addressing then add a supplement. Again, if it works then cool, but if it doesn't then it's dropped and something else tried.

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I think I like the anti depressants with a buspar like chemical because my response seemed to be good when I was feeling good.

So you felt good when taking Viibryd, but only if things were great anyway? What about when things weren't going so well?

Viibryd and Brintellix do the same thing. If Viibryd wasn't a great success then Brintellix may not be either. A SSRI plus Buspar may be a better option as the ratio can be fine tuned.

What happened when you were on Wellbutrin? Did you always take it with the other meds, or were you on it alone for a while?

Ian

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NOTE: I'm not a doctor, and particularly not yours, so there may be factors I'm unaware of. Therefore all advice is of a general nature and you should consult your doctor before following any of it, especially before changing med doses.

Offline dannysmiles19

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Re: Latuda as monotherapy or adjunct, gotta love the merry-go-round
« Reply #16 on: August 24, 2014, 08:11:14 PM »
The Wellbutrin was given to me in the hospital and it was with seroquil and later remeron as well. It was never on its own. Wellbutrin was not the right chemical for monotherapy for me at least. Viibryd alone just wasn't effective is what im saying. when it reached therapeutic levels, I was surviving, not quite living. I was alive, but I was kinda dying because monotherapy wasn't enough and I went off abilify earlier in the year.

I think augmentation and/or adjunct therapy works with the anti depressant effect because it seems to me that there is mood instability tendencies within a possible unipolar diagnosis. I think I have bipolar tendencies without a mood stabilizer but maybe not actual bipolar disorder.

In any case, viibryd was effective, just not effective without an adjunct agent. If I were to measure myself on the depression scale they use, I would say I had very obvious residual features. But adjunct treatment has pushed me closer to "remission" from symptoms. The psychotherapy part is a breeze, it's these damn meds that are a pain.

So, in conclusion, lol, thank you for conversing with me first and foremost. It takes a great deal of care to be doing what you've been doing for all of these people. It's phenomenal to give the time and opinion. But secondly, I think I like Latuda being on board along with lamictal. I think these other meds with the antidepressant must be the go to method for me. So now the only issue left is discerning what meds are needed and which ones are just being pumped into my body unnecessarily. Lamictal may be a crucial piece of my puzzle. You make the argument that Vortioxetine is basically viibryd, however, it is another drug. So it is quite possible that this drug may serve me well in my life.
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Re: Latuda as monotherapy or adjunct, gotta love the merry-go-round
« Reply #17 on: August 24, 2014, 09:23:30 PM »
You make the argument that Vortioxetine is basically viibryd, however, it is another drug. So it is quite possible that this drug may serve me well in my life.

They are both SSRIs with 5-HT1a receptors agonist properties which is the primary Buspar target. Vortioxetine (Brintellix) may or may not work better than Viibryd. Only time will tell.

Ian
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NOTE: I'm not a doctor, and particularly not yours, so there may be factors I'm unaware of. Therefore all advice is of a general nature and you should consult your doctor before following any of it, especially before changing med doses.

Offline dannysmiles19

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Re: Latuda as monotherapy or adjunct, gotta love the merry-go-round
« Reply #18 on: August 28, 2014, 10:42:54 PM »
I'm having the notorious brain shivers and zaps. What is your take on "rebound depression"? Is the rebound effect a chemically induced phenomenon or is this my original state coming back as the drug leaves my body?

I'm stuck in a crossroads, Ian. I don't really know if I need maintenance therapy or if I can live life off of Anti Depressants. I feel very susceptible to further depressive states off of them, and my dad has pill shamed without really trying to. This isn't fun, but it's the kind of crap I have to deal with. I wanted to use the other word.

Why are there two dannys? why is there a Danny on psychiatric drugs and a danny off of them? My mind enters a different realm when off of them. I feel like my original, natural mood state returns and I am facing a decision to either stay drug free danny, or stay on pills to protect Danny from brain cooties. I may have even developed a dependence wherein I don't live life with my drug free body and brain. Ian, I guess all of this rambling comes down to the question of whether or not psychiatry is something I need in my life or not. Can I truly do as well as I have off of pills through holistic approaches? or is my brain truly suffering from a clinical illness that requires medication to treat a damaged brain? I'm so lost... I have a box of brintillex waiting to be started, and now I don't know what to do with myself.

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Re: Latuda as monotherapy or adjunct, gotta love the merry-go-round
« Reply #19 on: August 28, 2014, 11:38:43 PM »
I'm having the notorious brain shivers and zaps. What is your take on "rebound depression"? Is the rebound effect a chemically induced phenomenon or is this my original state coming back as the drug leaves my body?

The brain shivers and zaps are short-term withdrawal symptoms as brain scrambles to adjust to the new circumstances and then over time the changes the antidepressant created may unravel.

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Can I truly do as well as I have off of pills through holistic approaches? or is my brain truly suffering from a clinical illness that requires medication to treat a damaged brain? I'm so lost.

Given this is something you've had for some time it probably won't just go away on its own. If you don't want to take meds then you're only other real option is psychotherapy. The cognitive/behavioural/mindfulness therapies can be as effective as antidepressants. But neither is a cure.

Ian
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NOTE: I'm not a doctor, and particularly not yours, so there may be factors I'm unaware of. Therefore all advice is of a general nature and you should consult your doctor before following any of it, especially before changing med doses.

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