I've been on 20 mg delayed-release capsules of Cymbalta for about 2-3 months now. The first week or two I was like "uh...what the heck." (This is the first drug I have tried for my depression/anxiety so I didn't know what to expect.) But the first week I had a few symptoms: headache, dizziness, yawning, sweating, trouble falling asleep, and also when I was going throughout my day I felt like I was moving really choppy like a cartoon character. After about 2 weeks I felt awesome. I don't really have any more side effects. Cymbalta definitely helps with depression, bad thoughts, and anxiety. It even helped me have more energy, confidence, and I am better at focusing. If I have to be on this drug for the rest of my life, I have no objections. I love it!