interesting to read of others setbacks, I am going thru one too though today was better. In the past I don't remember too many setbacks one the ad of the time started really working, but on the rare occasion where I would feel more than normal anxiety a bit of klonipin would quell it if taken as needed. This time I am on 1mg klonopin daily, more if its really bad, and the ad meds haven't been as effective yet as in the past, but I cant say they are doing nothing either, since I have had good days and even weeks. Still playing around with them trying to find the right one or right combo for me this time around. I like myocdragons take on setbacks, it is hard to realize in the midst of one that it will ever get better and I do fear that it might be a full on relapse and that I am med resistant but then again, the worst prediction is most often not the correct prediction. Plus I know well the morning thing, yes mornings are the worst, even on a bad day I know the evening will be better, on a good day it will be awesome. I do believe it is the cortisol level spiking at that time. I have often wondered why there aren't drugs that target cortisol, also since it comes from the adrenal glands, if one of those was removed, would that help or fix anxiety (somehow I doubt it, or we would all be lining up for that surgery) by lowering cortisol levels?