Has anyone had success with any other classes of antidepressants? I have GAD/PTSD and moderate depression.
I have been on tricyclic antidepressants (TCAs) for over 27 years. They are highly effective meds which have been eclipsed by SSRIs not because they are less effective, arguable they are more so, especially for depression, but because they have more ongoing side-effects such as constipation, which may be an advantage in your case.
I was on another forum and a few mentioned having success with Mirtazapine. I mentioned that to my GP and she said she only prescribes that for older people, for instance in a care home that tend to "wander" and it helps with keeping them down.
Mirtazapine is actually one of the two (with Effexor (venlafaxine)) most effective antidepressants for very severe depression. However, it is also the antidepressant most likely to stop working, often within only a few months.
I guess my take away on that one is that I wouldn't have much energy. I know it is good for sleep so maybe it makes you tired the rest of the time also.
Mirtazapine is a very sedating antidepressant and there can be some hangover during the day.
started taking Tryptophan to help increase my serotonin, hoping that would help.
NO!!!!!!!!!!!!!!!!!!!!!! Snake oil. Potentially very dangerous snake oil. See: Serotonin: The 'chemical imbalance' myth
Adding vitamin B6 doesn't increase the ability of L-Tryptophan to cross the blood-brain-barrier. All you're doing is producing more expensive urine, and maybe upsetting your gut in the process. Most of the serotonin produced in the body is synthesized and used by the enteric nervous system
, the mini brain that controls the gut. Around 95% compared to less than 2% by the brain.
Antidepressants do not work because they change the levels of a neurotransmitter in either the synapses, or the brain generally. While they may do so, this seems to be an consequence of the therapeutic effect, not its cause. They work by stimulating the growth of new brain cells
in the hippocampal areas of the brain and increasing the strength of connections between cells and brain regions.
but I need to be doing something while I wait. Any suggestions would be very welcome
Both exercise and Omega-3 fatty acids/fish oil have been shown to increase hippocampal neurogenesis and can be effective treatments for mild anxiety, or depression. A 30 minute walk 4-5 times a week, and/or 4-6 x 1,000mg fish oil capsules (start with 1 and up by 1 very 3-4 days to avoid diarrhea) are going to do much more good than any amount of L-Tryptophan.