I split my TCA (clomipramine) dose up to morning, noon, and right before bed. The sedating effects wore off after about 2 weeks. I dose morning and noon to keep the levels steady throughout my waking hours, plus, a small amount of sedation keeps my anxiety from kicking in at all. I have had nothing but good results from TCAs once reaching a therapeutic dose. The worst of the start up side effects for me is the sedation/ fatigue of getting used to it, which usually hits quick, levels, and then turns quickly leaving you feeling better once the med kicks in.