No I definitely hear you... I agree, very strange to be feeling better after only mild decrease in 2 days.... but I do feel better. I still think it has to be the zoloft and I think this because that is an adverse reaction listed on the warnings from the pharmacy. I have several symptoms that coincide with an adverse reaction, such as in the following: Hyperreflexia on exam, a diagnosed sleep disorder, fasciculations, and the small bowel lymphocytosis. Those things are not side effects; those are adverse reactions not good meaning get off the zoloft as it is causing major disruption i think to the normal function of the autonomic nervous system. The only side effect of the zoloft I have is zero libido and inability to cry or feel strong emotions... it keeps me very even. I have had so much testing over the past year and nothing has been found so it has to be the zoloft because nothing else explains it. If anyone else reads this and needs their minds put to rest, I kind of know what I am talking about, I work in the medical community, been there, done that, talked to many patients with similar experiences, and so I base a lot of my thinking on what I hear from patients and what meds they are on and let me tell you the happiest people are people that are not on a lot of medications. Now, it is agreeable sometimes you need a little pick me up... but come on people... these people on megadoses of multiple antidepressants is just not good. So here is testing I have had done and everything is ruled out so my bet is the zoloft is causing the fasciculations and sleep disorder:
1. Brain MRI - normal. Only abnormal thing is congenital defect of veins which is NO BIG DEAL and poses no harm to me. (Developmental venous anomaly left temporal lobe).
2. EMG- performed on right side - normal. EMG only needs to be done on one side to show any pathological abnormalities.
3. On neurological exam - have hyperreflexia, which means exaggerated response to stuff like when they tap your knee and you kick your leg out, which is a normal response. Hyperreflexia can be found as adverse reaction to zoloft and other SSRIs.
4. Stool studies - negative. One time i had white blood cells in my stool, but only 1+ or 25%. WBCs are found when you have inflammation which can be from inflammatory bowel disease or infection. No infection in my case and no IBD. Although, 3 months later, I had stool study done which was positive norovirus and equivocal salmonella, so it is possible i had salmonella. Equivocal means the lab cannot tell if yes or no. I was experiencing bad diarrhea.... so i prob had it. Incidentally i did stool sample day before becoming super sick with norovirus, and by that, in a 24 hour period, i threw up 15 times and had watery diarrhea 17 times. I have not had any bowel issues since. Oh, and you don't need antibiotic for salmonella. THe body will naturally clear it in about 6 weeks. You can take an antibiotic for it, too though. Then, usually people experience post-infectious irritable bowel as the flora in the lumen repairs itself back to normal homeostatic levels.
5. EGD (upper endoscopy) - Normal esophagus. Normal stomach, mild gastritis. I see thousands of pathologies every year and everyone has mild gastritis, no big deal. Negative H pylori. Dudoenum- 1st and 2nd portion examined and entire length duodenum granular in appearance. THat means there is inflammation and endoscopically something is causing change in appearance so that is what it looks like. Biopsy comes back duodenal intraepithelial lymphocytosis and crypt hyperplasia, which can be indicative of celiac or systemic autoimmune disease, NSAID use. I do not use NSAIDS. I had celiac panel done then and I am not a carrier of DQ2 or 8 gene therefore there is like 1% chance i could have celiac disease. But since tissue transglutaminase levels are normal highly unlikely. Now, lymphocytosis i had is of small bowel, but microscopic colitis as in lymphocytic colitis of large intestine which is different, that is the colon, that has been seen to be side effect related to zoloft... So I wonder if zoloft effected my small intestine in that way. By the way duodenal IELS can also mean Crohn's Disease. So then i had colonoscopy with random biopsies and all normal, so no Crohn's or colitis of any kind at all. Duodenal IELs can also be indicative of small bowel bacterial overgrowth. So i had lactulose breath test done which came back suggestive of SIBO due to double peak hydrogen counts... I took xifaxin for 10 days.. didn't notice any difference. So never got a specific answer nor will i ever on that one. That is the mystery of the duodenal IELS lol.
I will have to type more when i get a chance if anyone is following my story