Most definitely, I had 31 years without serious anxiety or depression (ie whatever I experienced was transitory and easily managed) then when I had my first panic attack everything changed. In the decade or so between the three episodes I have endured (well I'm still dealing with episode three) I found, with medication and time, myself again and practically forgot about how it felt to be in the midst of this illness. For one thing, its normal not to feel physically sick/weak every day, let alone depressed or anxious without good reason. I am still a risk adverse person when I am in remission, as I was before I got sick, but still its like night and day. In between episodes agoraphobia goes away and I get more interested in travelling, my hobbies, other people, and exercising. Waking up is no longer a chore, and I can drink tea and even coffee sometimes, which I cannot even contemplate until my brain heals again.