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Author Topic: Celexa and Trazodone  (Read 248 times)

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Offline bmr86

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Celexa and Trazodone
« on: January 08, 2014, 10:47:16 PM »
Hi all, I've been given 20mg of celexa for GAD (been on about 3 weeks, hasn't fully kicked in yet) and for sleep I've been given up to 100mg of trazodone. Does anyone else take that much trazodone for sleep? It does help me a lot, so I am just hoping I don't need to worry about a drug interaction, pdoc didn't indicate one but I like to ask anyways, perhaps insights can share some knowledge?
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Re: Celexa and Trazodone
« Reply #1 on: January 08, 2014, 11:45:05 PM »
Hi all, I've been given 20mg of celexa for GAD (been on about 3 weeks, hasn't fully kicked in yet) and for sleep I've been given up to 100mg of trazodone. Does anyone else take that much trazodone for sleep? It does help me a lot, so I am just hoping I don't need to worry about a drug interaction,

No, this shouldn't be a problem. Trazodone is a biphasic drug which at low doses acts as an antihistamine becoming an antidepressant only at doses from 150-225mg/day. As a rule sedation tends to drop off at higher doses so it can be nearly as sedating at 25-50mg as at 100mg.

Ian
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NOTE: I'm not a doctor, and particularly not yours, so there may be factors I'm unaware of. Therefore all advice is of a general nature and you should consult your doctor before following any of it, especially before changing med doses.

Offline M.Edwards

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Re: Celexa and Trazodone
« Reply #2 on: January 09, 2014, 08:15:20 AM »
Hi all, I've been given 20mg of celexa for GAD (been on about 3 weeks, hasn't fully kicked in yet) and for sleep I've been given up to 100mg of trazodone. Does anyone else take that much trazodone for sleep? It does help me a lot, so I am just hoping I don't need to worry about a drug interaction, pdoc didn't indicate one but I like to ask anyways, perhaps insights can share some knowledge?

I used to take 50mg Trazadone and it would knock me out.  After a few months when my anxiety settled down I was able to just quit without any issues.
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Offline dh1972

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Re: Celexa and Trazodone
« Reply #3 on: January 09, 2014, 01:04:02 PM »
Hi all, I've been given 20mg of celexa for GAD (been on about 3 weeks, hasn't fully kicked in yet) and for sleep I've been given up to 100mg of trazodone. Does anyone else take that much trazodone for sleep? It does help me a lot, so I am just hoping I don't need to worry about a drug interaction,

No, this shouldn't be a problem. Trazodone is a biphasic drug which at low doses acts as an antihistamine becoming an antidepressant only at doses from 150-225mg/day. As a rule sedation tends to drop off at higher doses so it can be nearly as sedating at 25-50mg as at 100mg.

Ian

Ian,

I actually found 100 mg more sedating than 25-50 mg.  And I found 125 mg more sedating than 100 mg.

My sleep doctor told me the higher doses get more sedating until you get somewhere past 150 mg. 
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