I have my reservations in trusting a user's anecdotal experience especially when that user has only made two threads that are in relation to supplements and their potential positive impact on anxiety. This is, thus, a contextual point. I haven't seen a single post made by yourself about the positive interactions between an anxiety sufferer with respect to other innumerable strategies in helping alleviate anxiety nor have I seen any other posts that focused only on Saffron and your anti-inflammatory approach on anxiety. This partly forms a basis for my skepticism and suspicion towards your posts.
So to summarize: you don't trust strangers. That may be a sign of lack of empathic skills, ie, the inability or reduced ability to decipher to minds and intentions of others.
Myself, I don't trust people who say they are scientific, but then like you, blatantly lie or dramatically exaggerate the dangers of OTC supplements, when these dangers are virtually non-existent. You are not the only skeptic I have come across that lies like this. This is a common lie among skeptics, for some reason.
How can call you even call yourself rational, when you blatantly give false information about the dangers of OTC supplements, and yet completely fail to mention the very real dangers of certain pharmaceuticals. Have you ever questioned yourself over your own honesty and consistency?
Sure. My belief is that while a priori knowledge is not sufficient for understanding the efficacy of a supplement - whether it be Saffron or an anti-inflammatory substance - your a posteriori approach on anxiety treatment which (I feel) is broadly characterised more or less by a 'try it yourself' mentality ignores both an empirical problem and epistemological problem from a clinical perspective. Let me preface that by saying that obviously I try to see the merit of any potential treatment for anxiety from a scientific perspective.
My approach, like any good scientific approach, is both theoretical and empirical. I have provided a theoretical framework to explain the cause of generalized anxiety disorder. If you look at the scientific literature, there are no theoretical frameworks that can explain anxiety disorder biochemically. There is a huge gap in our knowledge here. Thus I came up with my own theory of the biochemistry of anxiety, which of course may be totally wrong, but it guided me in my experimental (and successful) choice of treatments. This theory is outlined in my threads, in case you ever feel curious enough to read about it. The empirical side of my approach comes from testing various drugs and supplements, to find out by experiment the ones that work.
And all you polemic about anecdotal, personal experience counting for nothing: that is bullshit. Go tell Alexander Fleming that anecdotal experience counts for nothing, when he just happened to observe the dead bacteria in his petri dish. Or Barry Marshall, when he proved by a single experiment on himself that Helicobacter pylori was the cause of gastric ulcers. You do know about these pivotal point in medical science, don't you? Thus contrary to you assertion, anecdotal experience can be absolutely fundamental to scientific progress.
Lastly, the epistemological problem is that we have 'what we know' vs. 'what we don't know' and also the length of what we do know - my belief resonates the former - I can only potentially support those lines of treatment for anxiety where there is an adequate breadth and quality of knowledge and evidence base for. Again, due to this, I tell users to be wary.
So to summarize: you are too wary to generate your own knowledge by trying medications, and noting the effect. Not even OTC supplements, that for the large part, are extraordinarily safe. Unfortunate for you, because this type of knowledge derived from personal testing can often be more pertinent that that gained from large averaged out studies, because it is tailor made for your metabolism. That is the major point you seem to miss with your almost religious adherence to the gospel truth of RCTs. Until you understand the shortcomings of that statistical approach, as well as its great powers, you will never grasp the ethos of "alternative health". I also don't like pseudoscience, and I don't really like the side of "alternative health" that embraces pseudoscience; but I do know that without some personal experimentation — the ethos of "alternative health" — you get nowhere fast. This is also the case with trying standard drugs. Sometimes certain antidepressant or anti-anxiety drugs just suit you, and others don't, and the only way to find which drug work best for you is just by trying them experimentally. Good doctors do this all the time with their patients, trying various drugs by trial and error until they hit the right one.
Anyway, I am going ask a moderator to remove all these off-topic posts from this thread, and put them elsewhere, because is has messed up the normal flow of the topic I started. This also happened to my last thread that examined the studies on saffron.
Or I might just start a new thread, and just dump this one. In any case, I kindly ask you not to hijack the flow of my threads in future.